CD43 interferes with T-lymphocyte adhesion.

CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis.

CD43 is a major membrane sialoglycoprotein expressed by cells of hematopoietic origin. One property of CD43 is its ability to interfere with heterotypic and homotypic cellular adhesion. To determine whether CD43 expression can affect cell functions requiring intercellular adhesion, we compared a CD43-positive human T cell line (CEM) and its CD43-negative counterpart derived by gene targeting fo...

T Lymphocyte Adhesion to Human Brain Pericytes

T Lymphocyte Adhesion to Human Brain

Development of the Thymus Interferes with T Lymphocyte Highly Pathogenic Influenza Virus Infection

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.

HIV-1 negative factor (Nef) elevates virus replication and contributes to immune evasion in vivo. As one of its established in vitro activities, Nef interferes with T-lymphocyte chemotaxis by reducing host cell actin dynamics. To explore Nef's influence on in vivo recirculation of T lymphocytes, we assessed lymph-node homing of Nef-expressing primary murine lymphocytes and found a drastic impai...